Abstract: The subject of this research is the peculiarities of the work of Prosecutor’s Office of the Russian Federation pertinent to protection of citizens’ rights to essential medicines. The article examines the questions of legal regulation on the citizens’ access to essential medicines, as well as the powers of the Prosecutor’s Office in this regard. The authors meticulously analyze the results of prosecutors’ oversight activities in different subjects of the Russian Federation for the past two years. Special attention is given to the prosecutors’ work on eliminating violations and introducing recommendations on lodging complaints with the court. The scientific novelty lies in the comprehensive study of legal issues related to the protection of citizens’ right to essential medicines by the Prosecutor’s Office of the Russian Federation. Among the most meaningful results obtained in the course of this research is the formulation of proposition on improving the current legislation on the protection of citizens’ health, subject of prosecutor’s oversight and administrative liability for violating citizens’ rights, as well as the established law enforcement practice.