Abstract: The subject of this research is the Iraq War and its impact upon the international relations. The author examines the domestic causes for war, as well as external factors that predetermines its transition into the acute, military phase. The article analysis its effect upon the entire range of international relations in the region, as well as defines the position of leading countries of the Near and Middle East regarding the conflict around Iraq. Special attention is given to the foreign political strategy of the United States in the zone of Persian Gulf alongside the project of creation of the Large Near East. The author applies the most recent publications in Arab and English languages, some of which are introduced into the scientific discourse for the first time. This allows conducting a comprehensive analysis of the task at hand in the context of serious transformations within the system of international and regional relations. As a result of this work, the author was able to identify the most essential factor.