Abstract: One of the most frequent pathologies that a veterinarian encounters in practice is dermatitis of various etiologies. According to statistics, the number of visits of patients with dermatological diseases increases every year. One of the factors provoking the susceptibility of an animal to allergens is the current environmental conditions.Treatment of skin infections and allergies in domestic animals remains a problem that needs to be addressed. It is known that an important component of the pathogenesis of allergic dermatitis accompanied by further infectious, in particular bacterial dermatitis, is the cytokine factor. The aim of the work is to study the level of the main classes of cytokines in bacterial eczema and the effect of Apoquel on the change in these indicators.

Keywords: TNFα, Eczema, Oclacitinib, dermatitis, immunity, interleukins, cytokines, Pyrogens, Allergy, Lymphocytes

References:
Abramov V.V., Abramova T.Ya., Gontova I.A., Kozlov V.A., Markova E.V., Poveshchenko A.F., Rebenko N.M., Solov'eva I.G., Sorokin O.V. Zolotaya seriya natsional'nykh nauchnykh dostizheniy. Osnovy neyroimmunologii.-Moskva: 2004.-100 s.
Kozlov V.A. Gomeostaticheskaya proliferatsiya limfotsitov v aspekte immunopatogeneza razlichnykh zabolevaniy. // Immunologiya. 2006. T.27, №6. S. 378-382.
Ann Sophie Lønnberg, Claus Zachariae, and Lone Skov. Targeting of interleukin-17 in the treatment of psoriasis. Clin Cosmet Investig Dermatol. 2014; 7: 251–259.
Dhand A1, Aminoff MJ. The neurology of itch. Brain. 2014 Feb;137(Pt 2):313-22. doi: 10.1093/brain/awt158. Epub 2013 Jun 22.
Gonzales, AJ; Bowman, JW; Fici, GJ; Zhang, M; Mann, DW; Mitton-Fry, M (August 2014). "Oclacitinib (Apoquel®) Is a Novel Janus Kinase Inhibitor with Activity Against Cytokines Involved in Allergy". Journal of Veterinary Pharmacology and Therapeutics. 37 (4): 317–24.
Lenarczyk A., Le T.T., Drane D., Malliaros J., Pearse M., Hamilton R., Cox J., Luft

Abstract: The research subject is the analysis of scientific works studying the ways of cats infestation  with Opisthorchis felineus and the most common clinical symptoms of the disease. The article denotes the infestant of the invasion and its bridging host. The author considers the effectiveness of medications with active ingredients praziquantel and albendazole and treatment contradictions; analyzes the side effects of medications containing the above mentioned active ingredients on a cat’s organism; gives the examples of trade names with these active ingredients. The research method is the analysis of works studying the impact of anthelmintic agents, used to treat Opisthorchis felineus invasions in cats, on a cat’s organism and their side effects. The scientific novelty of the study in determined by the need for a comparative assessment of the effectiveness of anthelmintic agents with the active ingredients praziquantel and albendazole for treating opisthorchiasis in cats due to the existing variety of anthelmintic medications with various active ingredients and different trade names present on the mass market. Based on the research, the author concludes about the necessity to study the spread of opisthorchiasis in carnivores on the territory of Moscow. It is necessary to study the factors of the pathogen transmission to pets and the effectiveness of anthelmintic agents, and to assess the risks of infection for people.
 

Keywords: anthelmintic, pancreas, liver, invasion, worms, flukes, opisthorchiasis, cat, praziquantel, albendazole

References:
Simpson, Dzh.U. Bolezni pishchevaritel'noy sistemy sobak i koshek: per. s angl./ Dzh.U.Simpson, R.U.Els; pod red. V.V. Gritsenko. – M.: Akvarium buk.-2003.-496 s.
Usha, B.V. Farmakologiya / B.V. Usha, V.N. Zhulenko, O.I. Volkova; red. V.N. Zhulenko.-M.: Kolos.-2003.-376 s.
Urkkhart, G., Ermur, Dzh., Dunkan, Dzh., Dann, A., Dzhennings, F. Veterinarnaya parazitologiya.-M.: Akvarium.-2000.-352 s.
Mozgov, I.E. Farmakologiya/ I.E. Mozgov.-M.: Agropromizdat.-1985.-414 s.
Panova, O.A., Napisanova, L.A., Glamazdin, I.G. Obsledovanie koshek na kishechnye i migratsionnye formy gel'mintozov v gorode Moskva.//Teoriya i praktika bor'by s parazitarnymi boleznyami.-2015. № 16 s.320-323
Patofiziologiya: uchebnik dlya meditsinskikh vuzov / pod red. Novitskogo V.V. [i dr.] – Tomsk: Izd-vo Tom. un-ta.-2001.-848 s.
Vidal', Spravochnik lekarstvennykh preparatov. - URL:https://www.vidal.ru/veterinar/milbemax-tablets-for-dogs.
Vidal'. Spravochnik lekarstvennykh preparatov. – URL: https://www.vidal.ru
Glamazdin, I.G., Sysoeva, N.Yu., Verkhovskaya

Abstract: The article studies differential diagnostic signs of anaplasmosis in animals. Currently, in the context of ensuring the stabilization of livestock farming, an important task is to reduce mortality and maintain the high level of animal reproduction. One of the factors causing loss of highly productive farm animals and reducing their reproductive ability is anaplasmosis. Favourable weather and climate conditions and breach or nonobservance of instructions requesting to carry out scheduled veterinary activities lead to wide distribution of the disease which damages the economic industry. Identification of anaplasm on the early stages of the disease is often difficult due to the peculiar form of the pathogen, necessitating the conduct of the most sensitive serological diagnostic methods. The decrease of economic and breeding value leads to compulsory slaughter and culling thus increasing the general economic losses of farms caused by anaplasmosis.The article presents the data about the distribution and differential diagnostic characters of anaplasmosis in animals, based on the analytical review of scientific sources and literature. The author establishes the widespread infestation of farm animals with Anaplasma agents. Chronicity and parasitosis are referred to as the main features of the course of the disease. The prevalence varies from 1.54% to 46.9% regardless of the habitat and the conditions of animal management which indicates the permanent presence of Anaplasma in tongue worms determining the high rates of circulation of the disease agents in farms. The decisive factor in anaplasmosis diagnosis is the positive result of microscopic examination of Romanovsky-Giemsa stained blood smears. Serological methods are essential for Anaplasma species identification. At the same time, one of the most significant tests is the immunofluorescence test.

Keywords: Serological methods, differentiation, revealing, diagnostics, Spread, focality, epizootology, pathogen, carrier, anaplasmosis

References:
Jifei Y. Molecular detection and characterization of Anaplasma spp. in sheep and cattle from Xinjiang, northwest China / Y Jifei, L Youquan, L Zhijie, L Junlong, N Qingli, R Qiaoyun, C Ze, G Guiquan, L Jianxun, Y Hong // Parasit Vectors. – 2015. – Vol. 8(108) – P. 3–6. Published online. doi: 10.1186/s13071-015-0727-3
Renneker S. Can Anaplasma ovis in small ruminants be neglected any longer? / S Renneker, J Abdo, D.E.A Salih, T Karagenç, H Bilgiç, A Torina, A.G Oliva, J Campos, B Kullmann, J. Ahmed, U Seitzer // Transbound Emerg Dis. – 2013. – Vol. 60. – P .105-112
Kocan K. M., de la Fuente J., Blouin E. F. et al. The natural history of Anaplasma marginale // Vet. Parasitol. – 2010. – Vol. 167. – P. 95–107.
D'yakonov, L.P. K epizootologii anaplazmoza ovets // Parazitologicheskie problemamy respublik Zakavkaz'ya i Severnogo Kavkaza. – M., Makhachkala, 1961. – S. 22-24
Sidorchuk, A. A. Anaplazmoz krupnogo rogatogo skota i ovets / A. A. Sidorchuk, A. A. Glushkov // Veterinariya s.-kh. zhivotnykh: nauch.

Abstract: The research subject is the search for new effective means and methods necessary for treatment and prevention of malignant breast tumors in small domestic animals. The development of breast tumors in cats and dogs is one of the most serious problems of modern veterinary medicine and veterinary oncology. Recent statistical data convincingly proves the increase in the incidence in carnivorous animals, so it is necessary to develop and implement new effective methods of diagnosis and treatment of malignant neoplasms. Modern methods of veterinary therapy have a direct impact on the tumor tissue, they are one of the most progressive methods of treating cancer. One of these new methods is photodynamic therapy, which is used mainly for the treatment of malignant tumors. The essence of the method is that under the influence of light of a certain wavelength, oxygen reacts with photosensitizers and as a result, tumor cells die and are replaced by connective tissue.PDT is an innovative method for the treatment of malignant tumors, which includes the use of photosensitizing substances and laser irradiation of cancer-affected tissues. This therapy has the great potential in treating breast tumors in carnivores. As an independent method, it can be used to treat malignant tumors especially in the presence of contraindications to other methods of treatment.

Keywords: oncology, cats, photosensitizer, photodynamic therapy, mammary gland, tumors, treatment, laser, photoditazin, light energy

References:
Bibina, I. Yu. Kompleksnyy podkhod k lecheniyu raka molochnoy zhelezy sobak i koshek / I. Yu. Bibina, A. S. Rykhlov // Voprosy normativno-pravovogo regulirovaniya v veterinarii. № 4 – 2010. – S. 59–62.
Glazunova L.A., Koneva A.V. Sravnitel'naya effektivnost' razlichnykh priemov pri lechenii novoobrazovaniy molochnoy zhelezy u sobak i koshek // Nauchnoe obozrenie. Referativnyy zhurnal. – 2015. – № 2. – S. 32-33.
Stranadko E.F., Ryabov M.V., Furletova N.M., Yashunskiy D.V., Nifant'ev N.E. Issledovanie antibakterial'noy aktivnosti fotodinamicheskoy terapii s novym fotosensibilizatorom khlorinovogo ryada v eksperimente in vitro // Lazernaya meditsina. – 2002. – T.6, Vyp. 1. – S. 44–47.
Yagnikov S.A., Kuleshova O.A., Kuleshova Ya.A., Kornyushenkov E.A. Fotodinamicheskaya terapiya vveterinarnoy praktike // Rossiyskiy bioterapevticheskiy zhurnal, №4, T.7, 2008. S. 67-71.
Yakunina M.N. Analiz zabolevaemosti i kliniko-morfologicheskoy kharakteristiki raka molochnoy zhelezy u sobak i koshek / M.N. Yakunina, E.M. Treshchalina, V.A. Golubeva, A.A. Shimshirt