Abstract: The subject of the study is the psychological features of the hospital adaptation of adolescents, depending on the profile of the disease (gastroenterological and neurological). The work is aimed at identifying clinical and psychological characteristics in conditions of hospitalization as a "target" for preventive support of socio-psychological adaptation of adolescents in the hospital. The materials of an empirical study are presented, 120 people took part in all stages, two groups of subjects (neurological and gastroenterological departments) with an equal number of participants, the same number of boys and girls, and equal average age in the groups (11±0.8) were selected for the forming experiment. The authors pay special attention to the identification of psychological correlates of adaptation, the consideration of which increases the effectiveness of psychological support in the hospital. According to the results of the implementation of the developed program, an improvement in the indicators of socio-psychological adaptation of adolescents, stabilization of emotional well-being and a positive attitude to the treatment process in the hospital was revealed. Psychodiagnostic methods were applied: the CMAS scale of explicit anxiety; The methodology for diagnosing socio-psychological adaptation by K. Rogers, R. Diamond; the Kettell test, 14PF/HSPQ, the Spielberger-Hanin anxiety scale. Methods of mathematical statistics: Spearman's rank correlation coefficient, Student's T-criterion Scientific novelty lies in the identification of psychological correlates of hospital adaptation depending on the disease profile. Conclusions were obtained: the presence of psychological support for the hospitalization process of children allows to reduce anxiety, improve attitude to treatment, consolidate a positive emotional state and stabilize the socio-psychological adaptation of adolescents in the hospital; it is advisable to implement a hospital adaptation program taking into account the psychological characteristics of adolescents, depending on the profile of the disease; hospital adaptation of the patients with the neurological profile is accompanied by anxiety particularities; psychological support can be carried out in the direction of activating self-presentation, creating situations with vivid impressions and interesting facts, supporting the positioning of a teenager as an adult, independent and responsible for his behavior and a clear mode of life in a hospital.