Abstract: This article is dedicated to the events that received the name of Guna Revolution and led to the autonomy of Comarca Guna Yala that belongs to the Republic of Panama. Guna Indians are one of the few peoples of the American Continent who were able to preserve integrity of their land, their authenticity, traditions, culture and beliefs, although it took them enormous efforts. The goal of this research consists in examination of causes that led to the rebellion, as well as its consequences for the Guna people. The authors of attempt to reconstruct the events and determine the crucial factor that affected successful outcome of the revolt. The scientific novelty is defined by the fact that the history of Guna Indians of the Republic of Panama alongside the events related to their struggle for the autonomy and self-identification did not receive due coverage within the Russian scientific publications. In the current era of globalization, which blurs the boundaries and differences, the preservation of authenticity and integrity of small, and often large, ethnic groups is more relevant than ever. One of the authors was able to visit Comarca Guna Yala and get acquainted with the lifestyle, culture and traditions of its inhabitants, as well as listen to their perspective on the historical events of 1925, which Guna Indians carefully preserve in their folk tradition of chants that sound on the sessions of Guna General Congress.